---
title: Monkeypox Update
---

![logo](https://seracare.com/Content/themes/Skin_Default/images/lgc_logo.png)

The Native Antigen Company is part of LGC Clinical Diagnostics - [Learn More](https://www.lgcclinicaldiagnostics.com/)

+44 (0)1865 595230 [nac.contact@lgcgroup.com](mailto:nac.contact@lgcgroup.com)

<https://thenativeantigencompany.com/basket/>

[![Native-Antigen-Company-1-1](https://digital.thenativeantigencompany.com/hs-fs/hubfs/1.%20Logos/Native-Antigen-Company-1-1.png?width=1000&height=216&name=Native-Antigen-Company-1-1.png "Native-Antigen-Company-1-1")](https://thenativeantigencompany.com/)

 Search

- [Products](https://thenativeantigencompany.com/products/) 
    - - [Antigens & Antibodies](https://thenativeantigencompany.com/product-category/antigens-and-antibodies/) 
                  - - [Adenovirus](https://thenativeantigencompany.com/adenovirus/)
                            - [Astrovirus](https://thenativeantigencompany.com/astrovirus/)
                            - [Bordetella pertussis](https://thenativeantigencompany.com/bordetella-pertussis/)
                            - [Borrelia](https://thenativeantigencompany.com/borrelia/)
                            - [Burkholderia](https://thenativeantigencompany.com/burkholderia/)
                            - [Campylobacter](https://thenativeantigencompany.com/campylobacter/)
                            - [Chikungunya Virus](https://thenativeantigencompany.com/chikungunya-virus/)
                            - [Chlamydia](https://thenativeantigencompany.com/chlamydia/)
                            - [Clostridium](https://thenativeantigencompany.com/clostridium/)
                            - [Corynebacterium diphtheriae](https://thenativeantigencompany.com/corynebacterium-diphtheriae/)
                            - [Crimean Congo Hemorrhagic Fever Virus](https://thenativeantigencompany.com/crimean-congo-hemorrhagic-fever-virus/)
                            - [Cytomegalovirus](https://thenativeantigencompany.com/cytomegalovirus/)
                            - [Dengue Virus](https://thenativeantigencompany.com/dengue-virus/)
                            - [Ebola Virus](https://thenativeantigencompany.com/ebola-virus/)
                            - [Enterovirus](https://thenativeantigencompany.com/enterovirus/)
                            - [Epstein Barr Virus](https://thenativeantigencompany.com/epstein-barr-virus/)
                            - [Escherichia coli](https://thenativeantigencompany.com/escherichia-coli/)
                            - [Giardia](https://thenativeantigencompany.com/giardia/)
                  - - [Hantavirus](https://thenativeantigencompany.com/hantavirus/)
                            - [Hepatitis A](https://thenativeantigencompany.com/hepatitis-a/)
                            - [Hepatitis B](https://thenativeantigencompany.com/hepatitis-b/)
                            - [Listeria](https://thenativeantigencompany.com/listeria/)
                            - [Hepatitis C](https://thenativeantigencompany.com/hepatitis-c/)
                            - [Hepatitis E](https://thenativeantigencompany.com/hepatitis-e/)
                            - [Herpes Simplex Virus](https://thenativeantigencompany.com/herpes-simplex-virus/)
                            - [Human Coronavirus](https://thenativeantigencompany.com/human-coronavirus/)
                            - [Human Immunodeficiency Virus](https://thenativeantigencompany.com/hiv/)
                            - [Human Metapneumovirus](https://thenativeantigencompany.com/human-metapneumovirus/)
                            - [Human Papillomavirus](https://thenativeantigencompany.com/human-papillomavirus/)
                            - [Human Parainfluenza Virus](https://thenativeantigencompany.com/human-parainfluenza-virus/)
                            - [Influenza](https://thenativeantigencompany.com/influenza/)
                            - [Japanese Encephalitis Virus](https://thenativeantigencompany.com/japanese-encephalitis-virus/)
                            - [Lassa Fever Virus](https://thenativeantigencompany.com/lassa-fever-virus/)
                            - [Legionella](https://thenativeantigencompany.com/legionella/)
                            - [Leptospira](https://thenativeantigencompany.com/leptospira/)
                            - [Marburg Virus](https://thenativeantigencompany.com/marburg-virus/)
                  - - [Mayaro Virus](https://thenativeantigencompany.com/mayaro-virus/)
                            - [Measles Virus](https://thenativeantigencompany.com/measles-virus/)
                            - [Mumps Virus](https://thenativeantigencompany.com/mumps-virus/)
                            - [Mycoplasma](https://thenativeantigencompany.com/mycoplasma/)
                            - [Neisseria gonorrhoeae](https://thenativeantigencompany.com/neisseria-gonorrhoeae/)
                            - [Nipah Virus](https://thenativeantigencompany.com/nipah-virus/)
                            - [Norovirus](https://thenativeantigencompany.com/norovirus/)
                            - [O'nyong'nyong Virus](https://thenativeantigencompany.com/onyongnyong-virus/)
                            - [Oropouche Virus](https://thenativeantigencompany.com/oropouche-virus/)
                            - [Parvovirus](https://thenativeantigencompany.com/parvovirus/)
                            - [Plasmodium](https://thenativeantigencompany.com/plasmodium/)
                            - [Powassan Virus](https://thenativeantigencompany.com/powassan-virus/)
                            - [Puumala Virus](https://thenativeantigencompany.com/puumala-virus/)
                            - [Respiratory Syncytial Virus](https://thenativeantigencompany.com/respiratory-syncytial-virus/)
                            - [Rhinovirus](https://thenativeantigencompany.com/rhinovirus-antigens-and-antibodies/)
                            - [Rift Valley Fever Virus](https://thenativeantigencompany.com/rift-valley-fever-virus/)
                            - [Ross River Virus](https://thenativeantigencompany.com/ross-river-virus/)
                            - [Rotavirus](https://thenativeantigencompany.com/rotavirus/)
                  - - [Rubella Virus](https://thenativeantigencompany.com/rubella-virus/)
                            - [Salmonella](https://thenativeantigencompany.com/salmonella/)
                            - [Saint Louis Encephalitis Virus](https://thenativeantigencompany.com/saint-louis-encephalitis-virus/)
                            - [SFTSV](https://thenativeantigencompany.com/severe-fever-with-thrombocytopenia-virus/)
                            - [Staphylococcus aureus](https://thenativeantigencompany.com/staphylococcus-aureus/)
                            - [Streptococcus pneumoniae](https://thenativeantigencompany.com/streptococcus-pneumoniae/)
                            - [Tick-Borne Encephalitis Virus](https://thenativeantigencompany.com/tick-borne-encephalitis-virus/)
                            - [Toscana Virus](https://thenativeantigencompany.com/toscana-virus/)
                            - [Toxoplasma gondii](https://thenativeantigencompany.com/toxoplasma-gondii/)
                            - [Trichomonas](https://thenativeantigencompany.com/trichomoniasis/)
                            - [Usutu Virus](https://thenativeantigencompany.com/usutu-virus/)
                            - [Vaccinia](https://thenativeantigencompany.com/vaccinia/)
                            - [Vibrio cholerae](https://thenativeantigencompany.com/vibrio-cholerae/)
                            - [Wesselsbron Virus](https://thenativeantigencompany.com/wesselsbron-virus/)
                            - [West Nile Virus](https://thenativeantigencompany.com/west-nile-virus/)
                            - [Yellow Fever Virus](https://thenativeantigencompany.com/yellow-fever-virus/)
                            - [Zika Virus](https://thenativeantigencompany.com/zika-virus/)
          - [Virus-Like Particles](https://thenativeantigencompany.com/product-category/all/virus-like-particles/) 
                  - - [Chikungunya Virus VLP](https://thenativeantigencompany.com/products/chikungunya-virus-vlp/)
                            - [Dengue Virus Serotype 1-4 VLP](https://thenativeantigencompany.com/products/dengue-virus-like-particles/)
                            - [Dengue Virus Serotype 1 VLP](https://thenativeantigencompany.com/products/dengue-virus-serotype-1-vlp/)
                            - [Dengue Virus Serotype 2 VLP](https://thenativeantigencompany.com/products/dengue-virus-serotype-2-vlp/)
                            - [Dengue Virus Serotype 3 VLP](https://thenativeantigencompany.com/products/dengue-virus-serotype-3-vlp/)
                            - [Dengue Virus Serotype 4 VLP](https://thenativeantigencompany.com/products/dengue-virus-serotype-4-vlp/)
                            - [Ebola Virus VLP](https://thenativeantigencompany.com/products/ebola-virus-like-particles/)
                            - [Japanese Encephalitis Virus VLP](https://thenativeantigencompany.com/products/japanese-encephalitis-virus-vlp/)
                            - [Mayaro Virus VLP](https://thenativeantigencompany.com/products/mayaro-virus-vlp/)
                            - [Norovirus GI.1 VLP](https://thenativeantigencompany.com/products/norovirus-gi-1-vlp/)
                            - [Norovirus GII.4 VLP](https://thenativeantigencompany.com/products/norovirus-gii-4-vlp/)
                            - [O’nyong’nyong Virus VLP](https://thenativeantigencompany.com/products/onyongnyong-virus-vlp-e1-e2-capsid-protein/)
                            - [Parvovirus VLP](https://thenativeantigencompany.com/products/parvovirus-vp2/)
                            - [Rubella Virus VLP](https://thenativeantigencompany.com/products/rubella-virus-strain-f-therien-vlp-spike-glycoprotein-e1-e2/)
                            - [Zika Virus VLP](https://thenativeantigencompany.com/products/zika-virus-vlp/)
          - [Virus Receptors](https://thenativeantigencompany.com/virus-receptors/) 
                  - - [ALL VIRUS RECEPTORS](https://thenativeantigencompany.com/product-category/all/virus-receptors/)
                            - [Arenavirus Receptors](https://thenativeantigencompany.com/arenavirus-receptors/)
                            - [Coronavirus Receptors](https://thenativeantigencompany.com/coronavirus-receptors/)
                            - [Filovirus Receptors](https://thenativeantigencompany.com/filovirus-receptors/)
                            - [Flavivirus Receptors](https://thenativeantigencompany.com/virus-receptors-proteins-antibodies/)
                            - [Herpesvirus Receptors](https://thenativeantigencompany.com/herpesvirus-receptors/)
                            - [Orthomyxovirus Receptors](https://thenativeantigencompany.com/orthomyxovirus-receptors/)
                            - [Paramyxovirus Receptors](https://thenativeantigencompany.com/paramyxovirus-receptors/)
                            - [Retrovirus Receptors](https://thenativeantigencompany.com/retrovirus-receptors/)
                            - [Togavirus Receptors](https://thenativeantigencompany.com/togavirus-receptors/)
          - [Toxins](https://thenativeantigencompany.com/product-category/all/toxins/) 
                  - - [Bordetella Pertussis FHA](https://thenativeantigencompany.com/products/bordetella-pertussis-fha-filamentous-hemagglutinin/)
                            - [Bordetella Pertussis Toxin](https://thenativeantigencompany.com/products/bordetella-pertussis-toxin/)
                            - [Bordetella Pertussis Toxin (Frozen)](https://thenativeantigencompany.com/products/bordetella-pertussis-toxin-frozen/)
                            - [Bordetella Pertussis Toxin (Glycerol)](https://thenativeantigencompany.com/products/bordetella-pertussis-toxin-glycerol/)
                            - [Cholera Toxin Subunit B](https://thenativeantigencompany.com/products/cholera-toxin-subunit-b/)
                            - [Clostridium Difficile Toxin A](https://thenativeantigencompany.com/products/clostridium-difficile-toxin-a/)
                            - [Clostridium Difficile Toxin B](https://thenativeantigencompany.com/products/clostridium-difficile-toxin-b/)
                            - [Clostridium Difficile Toxoid A](https://thenativeantigencompany.com/products/clostridium-difficile-toxoid-a/)
                            - [Clostridium Difficile Toxin A Ribotype 027](https://thenativeantigencompany.com/products/clostridium-difficile-toxin-a-ribotype-027/)
                            - [Clostridium Difficile Toxin B Ribotype 027](https://thenativeantigencompany.com/products/clostridium-difficile-toxin-b-ribotype-027/)
                            - [Clostridium Difficile Toxin A Ribotype 078](https://thenativeantigencompany.com/products/clostridium-difficile-toxin-a-ribotype-078/)
                            - [Clostridium Difficile Toxin B Ribotype 078](https://thenativeantigencompany.com/products/clostridium-difficile-toxin-b-ribotype-078/)
                            - [Clostridium Difficile Toxoid B](https://thenativeantigencompany.com/products/clostridium-difficile-toxoid-b/)
                            - [Diphtheria Toxin](https://thenativeantigencompany.com/products/diphtheria/)
                            - [Diphtheria Toxin, CRM197 Mutant](https://thenativeantigencompany.com/products/diptheria-toxin-crm197-mutant/)
                            - [Tetanus Toxoid](https://thenativeantigencompany.com/products/tetanus-toxoid-recombinant-heavy-chain-fragment-c/)
          - [Immunoassays](https://thenativeantigencompany.com/product-category/immunoassays/) 
                  - - [Borrelia Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/borrelia-immunoassays/)
                            - [Chikungunya Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/chikungunya-virus-immunoassays/)
                            - [Dengue Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/dengue-virus-immunoassays/)
                            - [Hantavirus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/hantavirus-immunoassays/)
                            - [Legionella Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/legionella-immunoassays/)
                            - [Measles Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/measles-virus-immunoassays/)
                            - [Mumps Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/mumps-virus-immunoassays/)
                            - [Plasmodium Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/plasmodium-immunoassays/)
                            - [Rubella Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/rubella-virus-immunoassays/)
                            - [Tick-borne Encephalitis Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/tick-borne-encephalitis-virus-immunoassay/)
                            - [Zika Virus Assays](https://thenativeantigencompany.com/product-category/all/immunoassays/zika-virus-immunoassays/)
          - [Veterinary](https://thenativeantigencompany.com/product-category/all/veterinary/) 
                  - - [African Swine Fever Virus](https://thenativeantigencompany.com/african-swine-fever-virus/)
                            - [Borrelia](https://thenativeantigencompany.com/borrelia/)
                            - [Bovine Coronavirus](https://thenativeantigencompany.com/bovine-coronavirus/)
                            - [Burkholderia](https://thenativeantigencompany.com/burkholderia/)
                            - [Canine Adenovirus](https://thenativeantigencompany.com/canine-adenovirus/)
                            - [Canine Coronavirus](https://thenativeantigencompany.com/canine-coronavirus/)
                            - [Canine Distemper Virus](https://thenativeantigencompany.com/canine-distemper-virus/)
                            - [Canine Heartworm](https://thenativeantigencompany.com/canine-heartworm/)
                            - [Canine Herpes Virus](https://thenativeantigencompany.com/canine-herpes-virus/)
                            - [Canine Parainfluenza Virus](https://thenativeantigencompany.com/canine-parainfluenza-virus/)
                            - [Canine Parvovirus](https://thenativeantigencompany.com/canine-parvovirus/)
                            - [Feline Calcivirus](https://thenativeantigencompany.com/feline-calcivirus/)
                            - [Feline Coronavirus](https://thenativeantigencompany.com/feline-coronavirus/)
                            - [Feline Herpes Virus](https://thenativeantigencompany.com/feline-herpes-virus/)
                            - [Feline Immunodeficiency Virus](https://thenativeantigencompany.com/feline-immunodeficiency-virus/)
                            - [Feline Leukemia Virus](https://thenativeantigencompany.com/feline-leukemia-virus-felv/)
                            - [Feline Parvovirus](https://thenativeantigencompany.com/feline-parvovirus/)
                            - [Leptospira](https://thenativeantigencompany.com/leptospira/)
                            - [Porcine Coronavirus](https://thenativeantigencompany.com/porcine-coronavirus/)
                            - [Toxocara](https://thenativeantigencompany.com/toxocara/)
                            - [Toxoplasma](https://thenativeantigencompany.com/toxoplasma-gondii/)
          - [Conjugation and Labeling](https://thenativeantigencompany.com/product-category/all/conjugation-labeling-kits/) 
                  - - [Live Cell Labeling](https://thenativeantigencompany.com/live-cell-labeling/)
                            - [Conjugation Kits](https://thenativeantigencompany.com/conjugation-kits/)
          - [Accessory Reagents](https://thenativeantigencompany.com/product-category/accessory-reagents/) 
                  - - [Buffers & Solutions](https://thenativeantigencompany.com/product-category/all/accessory-reagents/buffers-solutions/)
                            - [Donor Sera](https://thenativeantigencompany.com/product-category/all/accessory-reagents/donor-sera/)
                            - [Isotype Controls](https://thenativeantigencompany.com/isotype-controls/)
                            - [Lysate Controls](https://thenativeantigencompany.com/product-category/all/accessory-reagents/lysate-controls/)
                            - [Secondary Antibodies](https://thenativeantigencompany.com/product-category/all/accessory-reagents/secondary-antibodies/)
                            - [Streptavidin Conjugates](https://thenativeantigencompany.com/product-category/all/accessory-reagents/streptavidin-conjugates/)
          - [Matched Pair Antibodies](https://thenativeantigencompany.com/matched-pair-antibodies/)
- [Services](https://thenativeantigencompany.com/contract-services/) 
    - [Services](https://thenativeantigencompany.com/contract-services/)
    - [Vector Design](https://thenativeantigencompany.com/contract-services/#sec-vector-design)
    - [Protein Expression](https://thenativeantigencompany.com/contract-services/#sec-protein-expression)
    - [Protein Purification](https://thenativeantigencompany.com/contract-services/#sec-protein-purification)
    - [Antibody Generation](https://thenativeantigencompany.com/contract-services/#sec-antibody-generation)
    - [ELISA Development](https://thenativeantigencompany.com/contract-services/#sec-elisa-development)
    - [Endotoxin Testing](https://thenativeantigencompany.com/contract-services/#sec-endotoxin-testing)
- [Pipeline](https://thenativeantigencompany.com/about-us/product-pipeline/) 
    - [Pipeline](https://thenativeantigencompany.com/about-us/product-pipeline/)
    - [Coronavirus Pipeline](https://thenativeantigencompany.com/coronavirus-dashboard/)
- [About Us](https://thenativeantigencompany.com/about-us/) 
    - [About Us](https://thenativeantigencompany.com/about-us/)
    - [Management](https://thenativeantigencompany.com/about-us/management/)
    - [Our Mission and Values](https://thenativeantigencompany.com/about-us/quality/)
    - [News](https://thenativeantigencompany.com/about-us/events/)
    - [Events](https://thenativeantigencompany.com/about-us/news-and-events/)
    - [Careers](https://thenativeantigencompany.com/about-us/careers/)
    - [Customer Feedback](https://thenativeantigencompany.com/about-us/customer-feedback/)
    - [ISO9001 Certification](https://thenativeantigencompany.com/about-us/our-mission-and-values/)
- [Contact Us](https://thenativeantigencompany.com/contact-us/) 
    - [Contact Us](https://thenativeantigencompany.com/contact-us/)
    - [Distributors](https://thenativeantigencompany.com/contact-us/distributors/)
- [Resources](https://thenativeantigencompany.com/resources/) 
    - [Resources](https://thenativeantigencompany.com/resources/)
    - [Product Catalogue](https://thenativeantigencompany.com/wp-content/uploads/2020/05/2020-Product-Catalogue-2.pdf)
    - [SARS-CoV-2 eBook](https://thenativeantigencompany.com/choosing-the-right-reagents-for-your-coronavirus-immunoassay/)
    - [Dengue eBook](https://thenativeantigencompany.com/landing-page-dengue-ebook/)
    - [Zika eBook](https://thenativeantigencompany.com/get-your-zika-virus-ebook/)
    - [References](https://thenativeantigencompany.com/resources/references/)
    - [FAQ](https://thenativeantigencompany.com/resources/faq/)
    - [Posters, Hoodies and T-Shirts](https://thenativeantigencompany.com/merchandise/)
- [Blog](https://thenativeantigencompany.com/blog/)

# Monkeypox



# **Monkeypox is a zoonotic virus of the orthopoxvirus genus of the *Poxviridae* family, and is typically endemic in Central and West Africa.**

In recent weeks of May 2022 monkeypox cases have been reported globally; with confirmed cases concentrated in Europe and the US. The identification of confirmed and suspected cases of monkeypox with no direct travel links to an endemic area represents a highly unusual event. With an incubation period of 10 to 14 days many more cases can be expected over the weeks and months. Despite mild disease progression in most healthy individuals symptoms can be severe in immunocompromised patients, children, and pregnant women. There are no therapeutics, and early detection of infection becomes crucial for containment.

Modified Vaccinia Ankara (MVA), manufactured as a smallpox vaccine, provides protection against monkeypox. However, cross-protective immunity from smallpox vaccination will be limited to older persons, since populations under the age of 40 or 50 years no longer benefit from the protection afforded by prior smallpox vaccination campaigns.

The Native Antigen Company have moved to develop a series of antigens to support research into this disease.  Four core proteins P4A, P4B, VP8 and 39kDa protein, and the major envelope protein F13L are now in early development, and will be commercially available in the summer of 2022.

- P4A (A11L) is the most abundant protein in the virion, and will be presented as a precursor, consisting of the 62kDa peptide and the 23kDa protein. In vivo P4A undergoes proteolytic cleavage by the I7 protease. During the transition from immature to mature virion.
- P4B (A4L) is another major component of the virion core and will be presented as the mature protein without its propeptide.
- VP8 (L4R, P25K) is a major structural core DNA-binding protein and will be presented as the mature protein without its propeptide.
- 39kDa protein (A5L) is an immunodominant protein expressed late during infection and is present in the viral core.
- F13L is a critical component in the production of wrapped virions which is required for cell-to-cell spread of the virus, is a major envelop antigen of extracellular virions and is a target for phospholipase inhibitors like tecovirimat. This protein will have its two cysteine palmitoylation sites changed to alanine.

 

Please contact us to register your interest and book pre-release orders.

[![Contact Us](https://no-cache.hubspot.com/cta/default/20300467/bcecc554-665b-4140-b55d-c34ccaf449a2.png)](https://cta-redirect.hubspot.com/cta/redirect/20300467/bcecc554-665b-4140-b55d-c34ccaf449a2)

#### Join our mailing list

#### PAGES

- [Home](https://thenativeantigencompany.com/)
- [Products](https://thenativeantigencompany.com/products/)
- [Services](https://thenativeantigencompany.com/services/)
- [Resources](https://thenativeantigencompany.com/resources/)
- [About Us](https://thenativeantigencompany.com/about-us/)
- [Blog](https://thenativeantigencompany.com/blog/)
- [Contact Us](https://thenativeantigencompany.com/contact-us/)

#### SHOP

- [Basket](https://thenativeantigencompany.com/basket/)
- [Checkout](https://thenativeantigencompany.com/checkout/)
- [My Account](https://thenativeantigencompany.com/my-account/)

#### LEGAL

- [Terms & Conditions](https://thenativeantigencompany.com/terms-conditions/)
- [Privacy Policy](https://thenativeantigencompany.com/about-us/privacy-policy/)
- [Ecotricity](https://thenativeantigencompany.com/about-us/ecotricity/)

#### FIND US

- [LinkedIn](https://www.linkedin.com/company/the-native-antigen-company)
- [Twitter](https://twitter.com/nativeantigen)

The Native Antigen Company | Copyright 2025 | Registration Number: 7386339 | VAT Number: 102038475